Synonym: N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate
CAS Number: 717906-29-1
Empirical Formula (Hill Notation): C22H21F3N6O3S · xH2O
Molecular Weight: 506.50 (anhydrous basis)
MDL Number: MFCD21608515
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PF-431396 is a potent inhibitor of PYK2 and FAK kinases (IC50 = 11 and 1.5 nM, respectively). PF-431396 increases bone formation and protects against bone loss in ovariectomized rats.
Assay: ≥98% (HPLC)
Form: powder
Color: off-white to blue-gray
Solubility: DMSO: ≥10 mg/mL
Storage Temp.: 2-8°C