Synonyms: 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrochloride; MP-10 hydrochloride; PF-02545920 hydrochloride; PF-920 hydrochloride
Molecular Formula: C25H20N4O · HCl
Molecular Weight: 428.91
Linear Structural Formula: C25H20N4O · HCl
MDL Number: MFCD30489759
Purity: >=97% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntington's disease.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.