Synonyms: 5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate
Molecular Formula: C22H21Cl2N3O3 · C2H4O2
Molecular Weight: 506.38
Linear Structural Formula: C22H21Cl2N3O3 · C2H4O2
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-06726304 is a selective inhibitor of Histone-lysine N-methyltransferase EZH2 (enhancer of Zeste homolog 2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27) and is amplified and/or overexpressed in several human cancers including breast, prostate and lymphoma. PF-06726304 is a novel structural class of EZH2 inhibitor.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.