Synonyms: 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate; PF 06651600
Molecular Formula: C15H19N5O · C3H4O4
Molecular Weight: 389.41
Linear Structural Formula: C15H19N5O · C3H4O4
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-06651600 specifically targets the ATP (adenosine triphosphate)-binding domain of JAK3 (Janus kinase 3). Loss of function of JAK3 is associated with severe combined immunodeficiency syndrome.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.