Synonyms: 3-Cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide trihydrochloride; Benzenesulfonamide, 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-, hydrochloride (1:3)
Molecular Formula: C35H32F3N7O3S2 · 3HCl
Molecular Weight: 829.18
Linear Structural Formula: C35H32F3N7O3S2 · 3HCl
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-06456384 is a highly potent and selective inhibitor against voltage-gated sodium channel NaV1.7 (SCN9A; IC50 = 0.01, <0.1 , 75 nm against human, mouse, rat nav1.7, respectively, by conventional patch clamp; human nav1.7 ic50="0.58" nm by patchexpress electrophysiology) with>300-fold selectivity over other human NaVs (IC50 = 3 nM/NaV1.2, 5.8 nM/NaV1.6, 75 nM/NaV1.7, 314 nM/NaV1.1, 1.45 muM/NaV1.4, 2.59 muM/NaV1.5, 6.44 muM/NaV1.3, 26 muM/NaV1.8).
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