PF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole.
Synonyms: 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
Molecular Formula: C19H16ClNO3
Molecular Weight: 341.79
Linear Structural Formula: C19H16ClNO3
Purity: >=98% (HPLC)
Storage: room temp
Application: PF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy.
Biochem Physiol Actions: PF-06409577 preserves retinal pigment epithelium cells from UV radiation by activating AMPK (AMP-activated protein kinase) signaling. This orally bioavailable and possesses pharmacokinetic properties. PF-06409577 blocks de novo lipid and cholesterol synthesis pathways that shows a decrease in hepatic lipids and mRNA expression of markers of hepatic fibrosis.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.