Synonyms: 1-(4-((4-(Dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea; Gedatolisib; PKI-587
Molecular Formula: C32H41N9O4
Molecular Weight: 615.73
Linear Structural Formula: C32H41N9O4
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-05212384, also known as PKI-587 and Gedatolisib, is a dual phosphatidylinositol-3-kinase (PI3K) / mammalian target of rapamycin (mTOR) inhibitor. PKI-587 potently inhibited class I PI3Ks (IC50 vs PI3K-α = 0.4 nM), PI3K-α mutants, and mTOR. PF-05212384 inhibited growth of 50 diverse human tumor cell lines at IC50s<100 nm and has been in clinical trials in patients with advanced solid tumors. pf-05212384 has also been found to sensitize cells to radiation.<>
Legal Information: Sold for research purposes under agreement from Pfizer Inc.