Synonyms: 2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one; PF-4691502; PF04691502
Molecular Formula: C22H27N5O4
Molecular Weight: 425.48
Linear Structural Formula: C22H27N5O4
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-04691502 is a potent dual mTOR/PI3K inhibitor with Ki values of 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K delta, alpha, beta, gamma, and mTOR, respectively, with no significant inhibitory activity at more than 80 other protein kinases, including PI 3-K downstream kinases, and MAPK family members. PF-04691502 showed antitumor activity in several non-small cell lung carcer (NSCLC) xenografts and ovarian cancer cell lines. PF-04691502 is currently in clinical trials.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.