Synonyms: 1,5-Dihydro-6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one; 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; PF 4447943
Molecular Formula: C20H25N7O2
Molecular Weight: 395.46
Linear Structural Formula: C20H25N7O2
MDL Number: MFCD22665724
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-04447943 is a potent selective brain penetrant phosphodiesterase PDE9A inhibitor both potency (8 nM) and selectivity (>10 muM versus all the PDEs except PDE1C at >1 muM). It has been investigated for the treatment of cognitive disorders including Alzheimer's Disease. PF-04447943 increased neurite outgrowth and synapse formation in hippocampal neurons in culture, exhibited synaptic stabilization in an amyloid precursor protein (APP) transgenic mouse model, and improved memory and enhanced attention in several animal models.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.