Synonyms: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-pentanamide hydrobromide; Nirogacestat; PF 03084014 hydrobromide; PF 3084014 hydrobromide; PF-3084014 hydrobromide
Molecular Formula: C27H41F2N5O · HBr
Molecular Weight: 570.56
Linear Structural Formula: C27H41F2N5O · HBr
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-03084014 is a highly potent gamma-secretase inhibitor that reduces Abeta production in vitro. PF-03084014 does not show a paradoxical increase in plasma Abeta at low concentrations in both preclinical species and humans.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.