Synonyms: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide; PD 168393
Molecular Formula: C17H13BrN4O
Molecular Weight: 369.22
Linear Structural Formula: C17H13BrN4O
MDL Number: MFCD02179207
Purity: >=98% (HPLC)
Storage: room temp
Application: PD168393 has been used in the acute inhibition of ErbB4.
Biochem Physiol Actions: PD168393 is potent, cell-permeable, irreversible and selective inhibitor of EGF receptor (EGFR) tyrosine kinase and ErbB2. PD168393 has an IC50 value of 0.70 nM for EGFR, and is inactive against insulin, PDGFR, FGFR and PKC.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.