An inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively); blocks the activities of the FLT3 D835Y mutant, FLT3 with ITDs, and JAK2 with a V617F substitution (IC50s = 6, 20-180, and 220 nM, respectively); orally bioavailable, inhibiting tumor growth and metastasis in xenografts in mice.