Synonyms: (-)-(2R)-2-Propyloctanoic acid; (2R)-2-Propyloctanoic acid; (R)-(-)-2-Propyloctanoic acid; (R)-2-Propyloctanoic acid; Arundic acid; ONO 2506; ONO2506
Molecular Formula: C11H22O2
Molecular Weight: 186.29
Linear Structural Formula: C11H22O2
MDL Number: MFCD08458423
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: ONO-2506 (arundic acid; (R)-2-propyloctanoic acid) is an inhibitory astrocytes-modulating agent that exerts glioprotective effects against amyloid-beta-peptide (Abeta)-induced glial death in astrocyte cultures (50 muM ONO-2506 against 200 muM Abeta25-35, 24 hr; 1321N1 astrocytes) by decreasing both the intracellular and extracellular S100B levels. Blockade of astrocytic activation by ONO-2506 in vivo is shown to offer therapeutic efficacy in animal models of normal tension glaucoma (10 mg/kg po. mice), spinal cord injury (20 mg/kg/d ip or iv rats), brain seizure, ischemic stroke (10 mg/kg/d ip or iv rats), and Parkinson's disease (30 mg/kg ip mice).