Synonyms: 6-Oxo-4-trifluoromethyl-1,6-dihydro-pyridine-3-carboxylic acid [4-(4-methyl-piperazin-1-yl)-3'-morpholin-4-ylmethyl-biphenyl-3-yl]-amide
Molecular Formula: C29H32F3N5O3
Molecular Weight: 555.59
Linear Structural Formula: C29H32F3N5O3
MDL Number: MFCD18364451
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 that potently binds to WDR5. OICR-9429 inhibits the interaction of WDR5 with MLL1 and RbBP5 in cells. For full characterization details, please see OICR-9429 on the Structural Genomics Consortium (SGC) website.OICR-0547 is the negative control for the active probe, OICR-9429. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Other Notes: OICR-9429 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the OICR-9429 probe summary on the Chemical Probes Portal website.