Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.
Synonyms: 3,4-Dichloro-benzo[b]thiophene-2-carboxylic acid hydrazide
Molecular Formula: C9H6Cl2N2OS
Molecular Weight: 261.13
Linear Structural Formula: C9H6Cl2N2OS
MDL Number: MFCD01993639
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.