NUCLEOSIL® is a family of totally porous spherical silicas with a very pure and uniform SiO2 structure
- Wide acceptance as routine packings for very different fields of chromatography
- One of the first spherical silicas used in HPLC
- Developed in the early seventies, it became a world-renowned HPLC packing
- Still found in many analytical and preparative application
- An absolutely reliable choice in HPLC
- The largest variety of modified HPLC silicas available on the market
NUCLEOSIL® C8 ec:
- Endcapped, pore size 100 Å, particle size 5 µm
- Separation mechanism based on hydrophobic (van der Waals) interactions, slight residual silanol interactions
- Corresponding HPLC phase based on NUCLEODUR® high purity silica: NUCLEODUR® C8 ec
- Carbon content 9 %
NUCLEOSIL® C8:
- Not endcapped, available pore sizes 100, 120, and 300 Å
- Available particle sizes 3 µm, 5 µm, 7 µm and 10 µm
- Separation mechanism based on hydrophobic (van der Waals) interactions, noticeable silanol interactions
- pH stability at 20 °C: 2–8
- Carbon content depends on pore size ~3 % (300 Å) up to 8.5 % (100 Å)
Features
- Octyl modified silica phases for HPLC, USP L7
- Nonpolar phases for RP chromatography
- C8 ec: medium density modification, endcapped
- C8: not encapped
Recommended application
- General RP application in HPLC; shows lower retention than C18 phases