Synonyms: 4-[[6-(Cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-benzamide
Molecular Formula: C23H30N6O2
Molecular Weight: 422.52
Linear Structural Formula: C23H30N6O2
MDL Number: MFCD09264153
Purity: >=98% (HPLC)
Storage: 2-8C
Application: NU6140 has been used to study its effect on transcription factors NANOG, OCT4 (organic cation/carnitine transporter 4) and SOX2(SRY-box 2), involved in pluripotency of human embryonic stem (hES) cells and embryonal carcinoma-derived (hEC) cells.
Biochem Physiol Actions: NU6140 is known to downregulate the expression of survivin protein, which possesses antiapoptotic activity and is generally overexpressed in cancer cells.