Synonyms: 2-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-N-(4-methoxyphenyl)hydrazinecarbothioamide; NSC 671054; NSC 73304
Molecular Formula: C16H14N4O2S
Molecular Weight: 326.37
Linear Structural Formula: C16H14N4O2S
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells. Irrespective of variations in cell line background, NSC73306 consistently demonstrated a Pgp-potentiated MDR-selective toxicity. It appears that NSC73306 is transported into the cell by copper transporter 1 (CTR1, SLC31A1). It is not P-gp inhibitor.