Synonyms: (2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one; (E)-1-(2-Hydroxyphenyl)-3-(pyridin-3-yl)-2-propen-1-one
Molecular Formula: C14H11NO2
Molecular Weight: 225.24
Linear Structural Formula: C14H11NO2
MDL Number: MFCD00499170
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) that targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model.