Synonyms: 15-Carboxy-13-isopropylatis-13-ene-17,18-dioic acid; NSC15520
Molecular Formula: C24H34O6
Molecular Weight: 418.52
Linear Structural Formula: C24H34O6
MDL Number: MFCD00057343
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: NSC15520 is an inhibitor of the N-terminal protein interaction domain of Replication Protein A (RPA), the major single-stranded DNA binding protein in eukaryotes, which is required for DNA replication, DNA repair, DNA recombination, and DNA damage response signaling. It has been shown to block the association of RPA to p53 and RAD9. In pluripotent stem cells, NSC 15520 increased targeted nucleotide substitutions in CRISPER reactions using Cas9n and Cpf1. It has been used along with a group of other small molecules to achieve a 2.8 to 7.2-fold increase in precision gene editing with Cas9.