Chemical structure: peptidyl nucleoside, aminoglycoside antibiotic. Nourseothricin (NTC) is a mixture of the related compounds streptothricin C, D, E, and F.
Synonyms: ClonNAT; NTC
Storage: 2-8C
Application: Nourseothricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.
Biochem Physiol Actions: Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the beta-amino group of the beta-lysin.Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.
Other Notes: Keep container tightly closed in a dry and well-ventilated place.