Synonyms: 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone dihydrochloride; AG 337
Molecular Formula: C14H12N4OS · 2HCl
Molecular Weight: 357.26
Linear Structural Formula: C14H12N4OS · 2HCl
MDL Number: MFCD26960887
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Nolatrexed dihydrochloride is a water-soluble lipophilic quinazoline folate analog that exhibits potent antineoplastic activity. Nolatrexed is a potent thymidylate synthase inhibitor that inhibits thymine synthesis followed by inhibition of DNA replication.