N,N-Diisopropylethylamine, ReagentPlus(R), >=99%

Synonyms: N-Ethyldiisopropylamine; DIPEA; Ethyldiisopropylamine; 'Hünig's base’

CAS Number: 7087-68-5

Formula: C8H19N

Formula Weight: 129.24

Linear Formula: [(CH3)2CH]2NC2H5

MDL No.: MFCD00008868

Purity: >=99%

Boiling Point: 127 C(lit.)

Melting Point: <-50 C (lit.)

Density: 0.742 g/mL at 25 C(lit.)

Refractive Index: n20/D 1.414(lit.)

EC Number: 230-392-0

UNSPSC Code: 12352100

General description: N,N-Diisopropylethylamine, also known as Hünig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed for substitution reactions. It acts as an activator for chiral iridium N, P ligand complexes, which can be utilized in the hydrogenation of α, β-unsaturated nitriles. The influence of varying concentration of N,N-diisopropylethylamine on the synthesis of olvanil in the presence of lipase catalyst has been investigated.

Application: Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.

Application: N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.