N,N-Bis(phosphonomethyl)glycine, =98.0% (T)

Synonym: N-(Carboxymethyl)iminodi(methylphosphinic acid), Glyphosine

CAS Number: 2439-99-8

Empirical Formula (Hill Notation): C₄H₁₁NO₈P₂

Molecular Weight: 263.08

Beilstein Registry Number: 1884944

EC Number: 219-468-4

MDL Number: MFCD00056670

Biochem/physiol Actions
Anti-diabetic; delay onset of diabetes in non-obese NOD mice¹.

Packaging
Application: Complexing agent; pK-values: pK1: ·2, pK2: 2.0, pK3: 5.20, pK4: 6.77, pK5: 10.89

Anti-diabetic; delay onset of diabetes in non-obese NOD mice

Glyphosine binds to a pocket of MHC class II molecules I-Ag7 and DQ8, and modify T cell responses to the autoantigenic insulin B chain fragment 9–23 (B:9–23) peptide. Glyphosine stimulate IL-10 production and delay onset of diabetes in non-obese NOD mice.†