Synonyms: Nizatidine; LY 139037; N'-[2-[[[2-[(Dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N-methyl-2-nitro-1,1-ethenediamine; N-{2-[2-(N,N-Dimethylaminomethyl)-4-thiazolylmethylthio]ethyl}-N'-methyl-2-nitro-1,1-ethenediamine
Molecular Formula: C12H21N5O2S2
Molecular Weight: 331.46
Linear Structural Formula: C12H21N5O2S2
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Nizatidine is a potent and selective antagonist of histamine H2 receptors used for treatment of stomach and intestine ulcers. Also, it was recommended as a component of combination therapy for cancer treatment. New data indicate that it can be repurposed to treat subtypes of clear cell renal cell carcinoma (ccRCC) in patients expressing certain isoforms of the pyruvate kinase muscle type. Additionally, nizatidine increases utrophin A levels in in C2C12 myoblasts (relevant to Duchenne muscular dystrophy).