Nisin from Lactococcus lactis 2.5% (balance sodium chloride and denatured milk solids)

CAS Number: 1414-45-5

Empirical Formula (Hill Notation): C₁₄₃H₂₃₀N₄₂O₃₇S₇

Molecular Weight: 3354.07

MDL Number: MFCD00131724

PubChem Substance ID: 24897751

Biochem/physiol Actions
Antibiotic with bactericidal action. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots.
Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (requires chelator such as EDTA).

Nisin binds to cell wall precursor lipid components (lipid A portion) of bacteria and disrupts cell wall production. Nisin alters the cell membrane which results in the leakage of cytoplasmic components and destruction of the proton motive force.

Packaging
Package size based on weight of total solids.

Application
Nisin is a polycyclic lantibiotic produced by Lactococcus lactis. It is commonly used as a food preservative. It is used as a selective agent in cell culture for the isolation of gram-negative bacteria, yeast, and molds. Product N54764 has been used in bioassays to study posttranslational modification of nisin. Nisin is used to study food preservation.