Nimbolide is a limonoid tetranortriterpenoid with an alpha,beta-unsaturated ketone system and a delta-lactone ring.
Molecular Formula: C27H30O7
Molecular Weight: 466.52
Linear Structural Formula: C27H30O7
Purity: >=98%
Storage: -20C
Biochem Physiol Actions: Nimbolide exhibits anti-malarial, anti-bacterial, and anti-cancer activities. It has been shown to induce apoptosis in osteosarcoma cells and inhibits cell migration of these cells by modulating the expression of integrin avß5. In human renal carcinoma cells, nimbolide induced cell cycle arrest, DNA damage, and apoptosis.Nimbolide is a triterpene isolated from Azadirachta indica. It has been shown to modulate autophagy and apoptosis in pancreatic cancer.