Synonyms: N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide trihydrochloride; NG 25 trihydrochloride
Molecular Formula: C29H30F3N5O2 · 3HCl
Molecular Weight: 646.96
Linear Structural Formula: C29H30F3N5O2 · 3HCl
MDL Number: MFCD19443255
Purity: >=98% (HPLC)
Storage: 2-8C
Application: NG25 trihydrochloride has been used as a transforming growth factor ß (TGFß)-activated kinase 1 inhibitor (TAK1) in human umbilical vein endothelial cells (HUVECs) and pulmonary artery smooth muscle cells.
Biochem Physiol Actions: NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFbeta-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.
Other Notes: Light sensitive