A cell-permeable, selective inhibitor of calcineurin-mediated dephosphorylation of NFAT that does not disrupt other calcineurin-dependent pathways; disrupts NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and prevents the activation and proliferation of T cells both in vitro (~ 43% at 1 µM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).