Synonyms: (alphaS)-alpha-[[4-Amino-3-[2-(4-hydroxyphenyl)ethyl]benzoyl]amino]-benzenebutanoic acid 1,1-dimethylethyl ester
Molecular Formula: C29H34N2O4
Molecular Weight: 474.59
Linear Structural Formula: C29H34N2O4
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Neoseptin-3 stimulates the activity of mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (mTLR) independently of CD14 (cluster of differentiation 14). This activated mTLR4/ mTLR promotes canonical myeloid differentiation primary response gene 88 (MyD88) and toll-interleukin(IL) 1 receptor (TIR) domain-containing adaptor inducing interferon (IFN)-ß (TRIF)-dependent signaling. In addition, neoseptin-3 also stimulates tumor necrosis factor a (TNF-a), IL-6 and IFNß production in a dose-dependent manner.