powder
CAS Number 1405-10-3
Empirical Formula (Hill Notation) C23H46N6O13 · 3H2SO4 · xH2O
Molecular Weight 908.88 (anhydrous basis)
EC Number 215-773-1
PubChem Substance ID 24897532
Biochem/physiol Actions
Mode of action: binds to the 30S and in some cases the 50S subunit causing miscoding; inhibits initiation and elongation during protein synthesis.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of action: binds to the 30S and in some cases the 50S subunit causing miscoding; inhibits initiation and elongation during protein synthesis. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. Neomycin blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.
Caution
Protect from light and moisture.
Application
Neomycin is used in molecular biology as a selection agent for prokaryotic cells that have been transformed using the selectable marker gene (neo). It is also used to study ototoxic side effects of antibiotics, platelet-derived growth factor (PDGF) responses in C3H/10T1/2 C18 fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins 1,2,3. Product N1876 is supplied as a powder.