Synonyms: N-(4,6-Dimethylpyridin-2-yl)-4-(pyridin-4-yl)piperazine-1-carbothioamide
Molecular Formula: C17H21N5S
Molecular Weight: 327.45
Linear Structural Formula: C17H21N5S
Purity: >=98% (HPLC)
Storage: 2-8C
Application: NCT-503 Inactive Control has been used as a small molecule inhibitor of phosphoglycerate dehydrogenase in neuroblastoma cells.
Biochem Physiol Actions: NCT-503 Inactive Control is the inactive control probe for NCT-503, which is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 Inactive Control has an IC50 value >57 muM for PHGDH. NCT-503 has an IC50 value of 2.5 muM for PHGDH. NCT-503 Inactive Control is water soluble and has good stability, similar to NCT-503.