N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a silylating reagent which replaces the active hydrogen with tert-Butyldimethylsilyl group. The tert-Butyldimethylsilyl derivatives are found to be more resistant to hydrolysis and stable compared to trimethylsilyl (TMS) derivatives. This reagent is suitable for GC-MS analysis since it produces mass spectra, which can be easily interpreted. It is widely used for the silylation of different alcohols, thiols, phenols, carboxylic acids, amines, and amides.
Synonyms: MTBSTFA
Molecular Formula: C9H18F3NOSi
Molecular Weight: 241.33
Linear Structural Formula: CF3CON(CH3)Si(CH3)2C(CH3)3
MDL Number: MFCD00009671
Purity: >=99.0% (GC)
Density: 1.036 g/mL at 25 C (lit.)
Refractive Index: n20/D 1.402 (lit.)
Storage: 2-8C
Application: N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide may be used as a derivatizing reagent for the determination of methionine sulfoxide and methionine in blood plasma and chlorpyrifos, diazinon and their major metabolites in sludge and sludge-fertilized agricultural soils using gas-chromatography coupled to mass spectrometry technique.
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