Synonyms: 4-Amino-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; E3 Ligase ligand methylated negative control; Ligand for PROTAC(R) research
Molecular Formula: C14H13N3O4
Molecular Weight: 287.27
Linear Structural Formula: C14H13N3O4
Purity: >=98%
Storage: 2-8C
Application: N-Methylated pomalidomide is a ligand used as a negative control for pomalidomide (P0018) in the recruitment of the Cereblon (CRBN) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC(R) Degraders for Targeted Protein DegradationHijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4Targeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein Degradation