N-Hydroxytetrachlorophthalimide (TCNHPI) is an aryl-tetrahalogenated N-hydroxyphthalimide derivative. In combination with 1,4-diamino-2,3-dichloroanthraquinone (DADCAQ), it forms an efficient catalytic system for the oxidation of aromatic hydrocarbons using molecular oxygen under metal-free and aerobic conditions.
Synonyms: 4,5,6,7-Tetrachloro-2-hydroxy-1H-isoindole-1,3(2H)-dione; Tetrachloro-N-hydroxyphthalimide
Molecular Formula: C8HCl4NO3
Molecular Weight: 300.91
Linear Structural Formula: C8HCl4NO3
Application: New reagent enabling the electrochemical allylic C-H oxidation reaction developed by the Baran group. This method provides a scalable and sustainable alternative to current strategies based on toxic reagents or precious metals.
Other Notes: Electrochemical Allylic C–H Oxidation with N-Hydroxytetrachlorophthalimide (TCNHPI)Scalable and sustainable electrochemical allylic C–H oxidationA general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagentsNickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic AcidsPractical Ni-Catalyzed Aryl-Alkyl Cross-Coupling of Secondary Redox-Active Esters