Synonyms: NEM
CAS Number: 128-53-0
Formula: C6H7NO2
Formula Weight: 125.13
Linear Formula: C6H7NO2
MDL No.: MFCD00005509
Purity: >=98% (HPLC)
Boiling Point: 210 C(lit.)
Melting Point: 43-46 C (lit.)
Storage: 2-8C
Beilstein Registry Number: 112448
EC Number: 204-892-4
UNSPSC Code: 12352200
Application: Reagent for the covalent modification of cysteine residues in proteins.
Biochem/physiol Actions: Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Biochem/physiol Actions: Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.
Preparation Note: NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.
RTECS: UX9625000
RIDADR: UN 2928 8(6.1) / PGII
WGK Germany: 3
Flash Point(F): 163.4 F
Flash Point(C): 73 C
R Codes: 21-28-34-43
S Codes: 26-28-36/37/39-45
IOD Codes: T+
Symbol: GHS05, GHS06
Signal Word: Danger
Hazard Statements: H300-H311-H314-H317
Precautionary statements: P264-P280-P301 + P310-P305 + P351 + P338-P310