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Thermo Scientific

MTBSTFA and MTBSTFA+1% TBDMCS

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MTBSTFA and MTBSTFA+1% TBDMCS offer stable TBDMS (tert-butyldimethylsilyl) derivatization.

Derivatizes hydroxyl, carboxyl, thiol and primary and secondary amines
Typical yields are >96%
Provides TBDMS ethers that are 104 times more stable to hydrolysis than TMS ethers
Reaction byproducts are neutral and volatile
Derivatives have a high molecular concentration at M-57
Silylating potential increased by adding 1% TBDMS

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