Synonyms: N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide dihydrochloride
Molecular Formula: C25H34N6O · 2HCl
Molecular Weight: 507.5
Linear Structural Formula: C25H34N6O · 2HCl
Purity: >=98% (HPLC)
Storage: 2-8C
Application: MRT68921 dihydrochloride has been used:
•as a specific inhibitor of Unc-51-like kinase 1 (ULK1) in SH-SY5Y neuroblastoma cells
•as an inhibitor of ULK1 and ULK2 kinases in intrahepatic lymphocytes
•as a ULK1 inhibitor to test its effect on attenuation of autophagosome accumulation in ubiquitin-specific peptidase 24 (USP24) knockdown containing human neuroglioma H4 cells
Biochem Physiol Actions: MRT68921 is cytotoxic and acts on oxidative stress signals to kill cancer cells, making it an effective tumor therapy agent.