MDL No.: MFCD00282500
Storage: -20C
UNSPSC Code: 12352203
General description: The tryptophan hydroxylase 1 gene (TPH1) is a 444 amino acid protein encoded by the gene spanning 29 kbp with11 exons on human chromosome 11p15.3-p14. The enzyme is expressed in the gut, spleen, thymus, pituitary and also in the pineal gland.
Application: Monoclonal Anti-Tryptophan Hydroxylase antibody produced in mouse has been used in immunohistochemistry and immunoblotting.
Biochem/physiol Actions: The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan, which is a precursor to the neurotransmitter serotonin. Variation in the gene expression affects prefrontal cortex activation during response inhibition. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders. The encoded protein plays a vital role in regulation of cardiovascular function.
Immunogen: recombinant rabbit tryptophan hydroxylase.
Specificity: This antibody reacts specifically with tryptophan hydroxylase.
RIDADR: NONH for all modes of transport
WGK Germany: nwg