Synonyms: Anti-GTF2D; Anti-GTF2DI; Anti-SCA17; Anti-TATA box binding protein; Anti-TFIID
MDL No.: MFCD01322691
Storage: -20C
UNSPSC Code: 12352203
General description: TBP (TATA-binding protein) is encoded by the gene mapped to human chromosome 6q27. The encoded protein is a key constituent of RNA polymerase II transcription apparatus in eukaryotic cells.
Biochem/physiol Actions: The TBP (TATA-binding protein) gene encodes a subunit of TFIIIB (transcription factor IIIB) complex and recognizes the TATA box in the DNA. Thus, it plays an important role in RNA polymerase II transcription machinery. TBP is known to induce stress granule formation in hepatitis B viral infection. Mutation in the gene is associated with the development of spinocerebellar ataxia 17 (SCA17).
Immunogen: Drosophila TFIID complex.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Target description: TBP encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of tr
RIDADR: NONH for all modes of transport
WGK Germany: 3