SNRPB (small nuclear ribonucleoprotein-associated protein B) is an important constituent of the spliceosome. It codes for SmB/B' (small nuclear ribonucleoprotein polypeptides B and B1). It is located on human chromosome 20p13. SmB'/B are upregulated in all tissues excluding postnatal brain.
Synonyms: Anti-SNRPB1; Anti-Sm protein B; Anti-Sm-B; Anti-SmB/SmB; Anti-Small nuclear ribonucleoprotein associated protein B; Anti-snRNP-B
Storage: -20C
Application:
•Monoclonal Anti-SmB antibody produced in mouse has been used in:
•western blotting
•enzyme-linked immunosorbent assay (ELISA)
•immunoprecipitation
•immunocytochemistry
Biochem Physiol Actions: SNRPB (small nuclear ribonucleoprotein-associated protein B) mutations results in cerebro-costo-mandibular syndrome. Downregulation of SNRPB affects the upregulation and processing of RNA splicing machinery components. It also plays a major role in RNA stability.