Monoclonal Anti-Neurofilament 200 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The neurofilaments are one of the five major groups of intermediate filaments (IFs) and are found predominantly in cells or tissues of neuronal origin. They are composed of three major proteins of apparent molecular weights 68 kD, 160 kD, and 200 kD and are named as NEFL (light), NEFM (medium) and NEFH (heavy) respectively. Neurofilament proteins are synthesized in the neuronal perikarya, assembled to form filaments and then slowly transported within the axons towards the synaptic terminals.
Synonyms: NF200 Antibody - Monoclonal Anti-Neurofilament 200 antibody produced in mouse; Neurofilament Antibody; Nf200 Antibody; Monoclonal Anti-Neurofilament heavy chain
MDL Number: MFCD02263444
Storage: -20C
Application: Monoclonal Anti-Neurofilament 200 antibody produced in mouse has been used in
•immunohistochemistry
•immunolabeling
•immunofluorescence
Biochem Physiol Actions: Neurofilament heavy chain (NEFH) gene was recently identified to cause autosomal dominant axonal Charcot-Marie-Tooth disease (CMT2cc). This gene plays a role in the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS). The phosphorylation of neurofilament polypeptides has been suggested to modulate their function by influencing the interaction between neurofilament and cytoplasmic organelles.