Neurofilaments belong to the intermediate filament family and are expressed mainly in cells or tissues of neuronal origin. It is crucial for proper radial growth of axons.
Synonyms: Monoclonal Anti-Neurofilament medium chain
MDL Number: MFCD01322393
Storage: -20C
Application: Monoclonal anti-neurofilament 160 antibody has been used in
•Immunoblotting.
•Immunohistochemistry
•Immunofluorescence
Biochem Physiol Actions: Neurofilaments play a role in axonal calibre as they help in movement of an impulse down the axon. Their activity depends on phosphorylation of neurofilaments.Mutations of neurofilaments causes Charcot-Marie-Tooth (CMT) disease. Accumulation of neurofilaments has been observed in many human neurological diseases like Alzheimer's disease, progressive supranuclear palsy, diabetic neuropathy, and giant axonal neuropathy.