Myosins are actin-dependent motors that have 15 classes based on their phylogenetics . Myosin VI is an unconventional actin motor that moves towards the minus ends of actin filaments, which is opposite to the movement of conventional myosins.
MDL Number: MFCD02263784
Storage: -20C
Application: Monoclonal Anti-Myosin VI antibody produced in mouse has been used in:
•enzyme-linked immunosorbent assay (ELISA)
•immunoprecipitation
•western blot assay
•immunohistochemistry
Biochem Physiol Actions: Myosin VI is involved in the generation of cell shape change, cell motility, membrane remodeling and possibly in organelle and particle transport or tethering. It is also involved in membrane trafficking pathways in cultured mammalian cells where it is associated with the membrane ruffles and the trans-Golgi network. Myosin VI plays an essential role in the development of the mouse inner ear where it is expressed in the hair cell body, in the actin-rich cuticular plate at the base of the stereocilia and in the peri cuticular necklace region. Myosin VI gene mutations are involved in deafness and balance defects in the Snell's Waltzer mouse. Myosin VI is present in the Golgi complex and may regulate vesicular transport across the membranes.