Synonyms: ANTIGal-8; ANTILGALS8; ANTILectin, galectoside-binding, soluble 8; ANTIPCTA1; ANTIProstate carcinoma tumor antigen 1
Storage: -20C
UNSPSC Code: 12352203
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General description: Galectins specifically bind to β-galactosides. 15 mammalian galectins have been identified so far. Galectin 8 contains two CRDs connected by a short linker peptide.
Application: Monoclonal Anti-Galectin-8 antibody produced in mouse is suitable for immunoblotting at a working concentration of 1-2mug/mL using recombinant rat galectin 8 protein (Catalog No. G3670). It is also suitable for immunocytochemistry and indirect ELISA.
Biochem/physiol Actions: Galectins belong to a family of carbohydrate-binding proteins. These proteins share similarities in the carbohydrate recognition domain (CRD) and in their specificity for N-Acetyllactosamine-enriched glycoconjugates. The binding of galectins to saccharides modulates cell proliferation, cell death and cell migration, which are involved in cancer initiation and progression. Galectin 8 is a secreted protein that requires both of its CRDs to be active to modulate cell adhesion. It forms a complex with integrins and triggers integrin-mediated signaling cascades. On the contrary, excessive amounts of this protein negatively regulate cell adhesion by interacting with integrins. These signals assist in identifying regions available for cell adhesion and migration. It may be involved in neoplastic transformation.
Immunogen: recombinant rat galectin 8.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Specificity: The antibody has low cross-reactivity with galectin 3 and galectin 9.
RIDADR: NONH for all modes of transport