?-Aminobutyric acid (GABA) functions as an inhibitory neurotransmitter in the central nervous system. It also functions as a neuromodulator in some peripheral tissues. Additionally, GABA is present in non-nervous tissues and regulates blood pressure, heart rate, respiration, immunomodulation, cell proliferation, protein synthesis and metabolism.Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The antibody does not cross react with L-a-aminobutyric acid, L-glutamic acid, L-aspartic acid, glycine, d-aminovaleric acid, L-threonine, L-glutamine, taurine, putrescine, L-alanine and carnosine. However, weak cross-reaction is observed with ß-alanine and e-aminocaproic acid.
Synonyms: GABA Antibody - Monoclonal Anti-GABA antibody produced in mouse; Gaba Antibody Sigma; Anti-gamma-Aminobutyric acid
MDL Number: MFCD00162297
Storage: -20C
Application: Monoclonal Anti-GABA antibody produced in mouse has been used in immunohistochemistry and immunocytochemistry.
Biochem Physiol Actions: ?-Aminobutyric acid (GABA) mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.