Synonyms: BNIP-S; BNIPL-1; BNIPL-2; BNIPL1; BNIPL2; PP753
Storage: -20C
UNSPSC Code: 12352203
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General description: The gene BNIPL (Bcl-2/adenovirus E1B 19kDa interacting protein 2-like) encodes a protein containing BNIP-2 and Cdc42GAP homology (BCH) domain and has a molar mass of 19kDa. It is abundantly expressed in human placenta and lung.
Biochem/physiol Actions: The gene BNIPL (Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like) encodes a protein of the BNIPL family that functions in the apoptotic pathway. The BCH (BNIP-2 and Cdc42GAP homology) domain plays a crucial role by interacting with Bcl-2 and Cdc42GAP and inducing cell death. It serves as a linker protein in Bcl-2 pathway for DNA fragmentation. It also participates in Cdc42 (cell division control) signaling for changes in cell morphology and membrane blebbing during apoptosis. It facilitates invasion and cancer metastasis.
Immunogen: BNIPL (AAH27868, 1 a.a. ~ 275 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMRKRLSAPELRLSLTKGPGNDGASPTQSAPSSPDGSSDLEIDELETPSDSEQLDSGHEFEWEDELPRAEGLGTSETAERLGRGCMWDVTGEDGHHWRVFRMGPREQRVDMTVIEPYKKVLSHGGYHGDGLNAVILFASCYLPRSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLISLDQVHIPEAVRQLDRDLHGSGGT
Physical form: Solution in phosphate buffered saline, pH 7.4
RIDADR: NONH for all modes of transport
WGK Germany: 3