a-Fetoprotein (AFP) is a one of the main glycoprotein present in the fetal liver, gastrointestinal tract, and yolk sac. AFP levels in amniotic fluid have been used as biomarkers for anencephaly and spina bifida.
Synonyms: Afp Antibody; Afp Antibody - Monoclonal Anti-alpha-Fetoprotein (AFP) antibody produced in mouse; Alpha Fetoprotein Antibody
MDL Number: MFCD00162111
Storage: -20C
Application: Mouse Monoclonal Anti-a-Fetoprotein has been used for immunocytochemistry. The product can also be used for dot blot and indirect ELISA.
Biochem Physiol Actions: Increased concentrations of a-fetoprotein (AFP) in serum are less common in patients with malignancies of the gastrointestinal tract and of other organ systems with massive hepatic metastases. Hence, AFP determination is useful for the diagnosis of certain germ line tumors that contain yolk sac structures (testicular and ovarian tumors), hepatocellular carcinoma (hepatoma), and some malignant tumors of the gastrointestinal tract. AFP serves as an important marker for certain genetic and embryonic defects. Routine screening of pregnancies with a risk of neural tube defects (spina bifida, anencephaly, and Down's syndrome) may be facilitated by the monitoring of AFP levels.