Synonyms: 2-(2-Carboxy-6-naphthalenyl)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalen-2-yl)-1,3-dithiolane; 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid; MM 11253; MM-11253; SR 11253; SR11253
Molecular Formula: C28H30O2S2
Molecular Weight: 462.67
Linear Structural Formula: C28H30O2S2
MDL Number: MFCD19690917
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: MM11253 (SR11253) is a high-affinity RARgamma-selective retinoid acid (RA) receptor antagonist (IC50 = 44 nM against ATRA for binding RARgamma; IC50 =1 muM in case of RARalpha, RARbeta, RXRalpha) that prevents >90% growth inhibitory effect of retinoids AHPN/CD437 (1 muM in CA-OV3 & SK-SKOV3 cultures) and M11389 (1 muM in SCC-25 squamous cell carcinoma cultures) when used at equal concentration. MM11253 also effectively blocks the inhibitory effect of R667 (RARgamma agonist) against IL-1beta-induced MMP production from rabbit corneal fibroblasts (80% vs. 11% inhibition by 0,1 nM R667, respectively, without or with 0.03 nM MM11253).