Synonyms: N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide; N-[2-(4-Chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide
Molecular Formula: C14H14ClNO2S
Molecular Weight: 295.78
Linear Structural Formula: C14H14ClNO2S
MDL Number: MFCD01990273
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: ML402 is a selective activator of K2P2.1 (TREK-1) and K2P10.1 (TREK-2) potassium channels. It was used to determine a cryptic selectivity filter binding site of the K2P2.1 (TREK-1) channel, designated the K2P modulator pocket. This binding pocket stabilizes an active "leak-mode" conformation, binding small-molecule activators that restrict the mobility of the selectivity filter and surrounding structure.